Quality standards, including physical, chemical, and microbiological tests and criteria are important parts of the safety and efficacy of ingredients. Bonerge is aiming to offer premium-quality Apigenin ingredients with potent healthy values to the world.

1. You can tell the defferences between our NADHelp+ and other Apigenin ingredients very simply from the appearance and colour

2.  A full set of quality characterization make sure you get the ture and the best Apigenin

With professional analytical scientists and advanced equipments, top quality and consistency among batches are the golden promises to our customers from Bonerge.

The identity test, purity test, impurity test and assay test that usually applied in the pharmaceutical industry and guided by USP requirements, is at the center of Bonerge's quality research.

3. Authoritative and credible Reference Standard(RS) for assay analysis 

A trusted RS is like an impartial judge. Reference substances are of great importance for a test method.  Bonerge sourced Apigenin RS globall, after comparison and evaluation, we choosed a reputable German Reference Standard from Sigma as its external standard.

4.  Top quality botanical source for eco-friendly and cost-efficiently manufacturing

 We are making efforts to manufacture eco-friendly and cost-efficiently to make NADHelp+™ more affordable to consumers. We work with the raw material growers closely to source high quality material that can be traced through every step.  Our facility equipped with two continuous countercurrent extraction lines, and each line is available in capacities of up to 100 tons/day raw material, enable us to produce at super largre scale and achive the best quality and cost.

1. SIGNIFICANTLY REDUCE CD38 EXPRESSION AND INCREASE NAD LEVEL

CD38, a NADase, can result in age-related NAD decline. Apigenin is the best candidate to reduce CD38 expression to prevent partial consumption of NAD, thus to increase NAD level significantly. 

In vivo study, Apigenin down-regulated CD38 expression, and increased the intracellular NAD+/NADH ratio and Sirt3-mediated mitochondrial antioxidative enzyme activity in the kidneys of diabetic rats.

2. SUPPORT CARDIOVASCULAR AND HERT HEALTH

According to studies, Apigenin has been demonstrated to alleviate cardiovascular conditions by preserving the vascular lining in the aorta. It also induced the direct reduction of blood pressure by inhibiting of the activity of the angiotensin-converting enzyme, preventing blood vessel constriction.

3. MITIGATE UV INDUCED CELLULAR SENESCENCE IN SKIN, HELP TO REDUCE WRINKLES

In a skin health study, Apigenin can effectively inhibit cell senescence, and 20 μM apigenin can reduce the proportion of senescent cells by 3.5 times. On the other hand, Apigenin reduces the length of wrinkles by 25%, from 65mm before use to 48mm after 4 weeks of use.

4. RELIEVE DEPRESSION ANF AID SLEEP

Apigenin possesses antidepressant and antianxiety effects by selectively inhibiting the brain's monoamine oxidases (MAOs). A clinical trial has shown administering apigenin to individuals with depression and anxiety resulted in a significantly higher reduction in total Hamilton Depression Rating Scale (HDRS) score, which assesses the severity of depression symptoms in individuals.